Incidental Richter transformation in chronic lymphocytic leukemia patients during temporary …

Contribution: P.J.H., H.-J.J.C., N.J., and S.A.P. designed the study, collected and analyzed data, and wrote the manuscript; T.G.C., W.D., H.A.T., A.F., and W.G.W. cared for patients and critically reviewed the manuscript; M.K., E.D.M., R.N.M., and P.L. collected and analyzed data, performed pathology review, and critically reviewed the manuscript; and all authors approved the manuscript in its final format.

Conflict-of-interest disclosure: W.D. reports research funding has been provided to the institution from Merck and DTRM, and has participated in advisory board meetings of Octapharma and Alexion (she was not personally compensated for her participation). R.N.M. received honorarium from Allergan for participating at 1 advisory board conference. H.A.T. served as a consultant or an advisory board member for Bristol-Myers Squibb, Novartis, Merck & Co., Genentech, and Array and has received commercial research grants from Bristol-Myers Squibb, Merck & Co., Genentech, GlaxoSmithKline, and Celgene. A.F. reports research funding Celgene, Acerta, Beigene. W.G.W. reports grants from AbbVie, GlaxoSmithKline, Novartis, Genentech, Pharmacyclics, Gilead, Acerta, JUNO (Celegene), KITE Pharma (Gilead), Sunesis, Miragen, Oncturnal Therapeutics, LOXO Oncology, Cyclacel, Janssen, and Xencor, and nonfinancial support from AbbVie, Genentech, Pharmacyclics, Gilead, Acerta, JUNO (Celgene), KITE Pharma (Gilead), Sunesis, Oncturnal Therapeutics, LOXO Oncology, and Janssen outside the submitted work. N.J. reports research funding has been provided to the institution from Pharmacyclics, AbbVie, Genentech, AstraZeneca, BMS, Pfizer, ADC Therapeutics, Incyte, Servier, Cellectis, Verastem, Adaptive Biotechnologies, and Precision Biosciences for clinical studies in which N.J. is a principal investigator, and has participated in advisory board meetings and received honoraria from Pharmacyclics, Janssen, AbbVie, Genentech, AstraZeneca, Verastem, Adaptive Biotechnologies, Servier, and Precision Biosciences. S.A.P. reports research funding has been provided to the institution from Pharmacyclics, MorphoSys, Janssen, AstraZeneca, TG Therapeutics, Celgene, AbbVie, and Ascentage Pharma for clinical studies in which S.A.P. is a principal investigator, and has also participated in advisory board meetings of Pharmacyclics, AstraZeneca, Genentech, Gilead, GlaxoSmithKline, Verastem Oncology, and AbbVie (he was not personally compensated for his participation). The remaining authors declare no competing financial interests.

Correspondence: Paul J. Hampel, Division of Hematology, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: [email protected]

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